Download Bacterial Virulence Factors and Rho GTPases by B. B. Finlay (auth.), Patrice Boquet, Emmanuel Lemichez PDF

By B. B. Finlay (auth.), Patrice Boquet, Emmanuel Lemichez (eds.)

Pathogenic micro organism for human and animals have constructed subtle guns, termed virulence elements, to make sure their replication and endurance into their hosts. the 1st position of those virulence components is to loosen the host defenses opposed to microorganisms represented through innate and adaptive immunities. Small GTPases of the Rho subfamily were proven best play vital features in theses platforms.

The authors of this quantity current the synthesis on how many of the host mobile Rho GTPases actions are manipulated through micro organism to satisfy their virulence.

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Additional resources for Bacterial Virulence Factors and Rho GTPases

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32 3 Molecular Function of SopE . . . . . . . . . . . . . . . . 32 4 Structure of the SopE*Cdc42 Complex: Molecular Mimicry . . . . . 33 5 G-Nucleotide Exchange Catalyzed by SopE Versus EDTA . . . . . . 35 6 Signaling of SopE Proteins Inside the Host Cell . . . . . . . . . . 36 7 Identification and Domain Structure of SptP . . . . . . . . . . 36 8 The GAP Domain of SptP . . . . . . . . . . . . . . . . . 37 9 Structure of the SptP-GAP*Rac1 Complex .

S. VanLoock, E. H. Egelman, and C. E. Stebbins. 2003. Salmonella SipA polymerizes actin by stapling filaments with nonglobular protein arms. Science 301:1918–21. 25. McGhie, E. , R. D. Hayward, and V. Koronakis. 2004. Control of actin turnover by a salmonella invasion protein. Mol Cell 13:497–510. 26. McGhie, E. , R. D. Hayward, and V. Koronakis. 2001. Cooperation between actinbinding proteins of invasive Salmonella: SipA potentiates SipC nucleation and bundling of actin. EMBO J 20:2131–9. 27. , K.

37 9 Structure of the SptP-GAP*Rac1 Complex . . . . . . . . . . . 37 10 SopE Yin-SptP Yang . . . . . . . . . . . . . . . . . . . 39 References . . . . . . . . . . . . . . . . . . . . . . . . . 39 Abstract Salmonella Typhimurium uses the type III secretion system encoded in the Salmonella pathogenicity island I (SPI-1 TTSS) to inject toxins (effector proteins) into host cells. Here, we focus on the functional mechanism of three of these toxins: SopE, SopE2, and SptP.

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