Download Ciba Foundation Symposium 90 - Receptors, Antibodies and PDF

Chapter 1 creation (pages 1–2): N. A. Mitchison
Chapter 2 Structure?Function Relationships in Adenylate Cyclase structures (pages 3–21): Martin Rodbell
Chapter three The Immunological foundation of Autoimmune affliction (pages 22–34): I.M. Rott and L.C. De Carvalho
Chapter four The Genetic foundation of Autoimmune affliction (pages 35–56): J. G. Knight and D. D. Adams
Chapter five T mobile reputation and interplay within the Immune method (pages 57–81): N. A. Mitchison
Chapter 6 Insulin Receptors and Insulin Receptor Antibodies: Structure?Function Relationships (pages 82–90): Steven Jacobs and Pedro Cuatrecasas
Chapter 7 Autoantibodies to Insulin Receptors in guy: Immunological Determinants and Mechanism of motion (pages 91–113): C. Ronald Kahn, Masato Kasuga, George L. King and Carl Grunfeld
Chapter eight Structure?Function relatives of the Thyrotropin Receptor (pages 114–132): B. Rees Smith and P. R. Buckland
Chapter nine Thyrotropin Receptor Antibodies: Clinico?Pathological Correlations (pages 133–152): R. corridor, S. McLachlan, M. McGregor, A. P. Weetman and B. Rees Smith
Chapter 10 Thyroid Antibodies in Thyroid ailments (pages 153–177): G. F. Bottazzo, H. A. Drexhage and E. L. Khoury
Chapter eleven constitution of the Acetylcholine Receptor and Specificities of Antibodies to it in Myasthenia Gravis (pages 178–196): Jon M. Lindstrom
Chapter 12 Mechanisms of Acetylcholine Receptor Loss from the Neuromuscular Junction (pages 197–224): Andrew G. Engel and Guido Fumagalli
Chapter thirteen Acetylcholine Receptor Antibody: medical and Experimental features (pages 225–247): John Newsom?Davis, Angela Vincent and Nick Willcox
Chapter 14 Atopy, Autonomic functionality and ??Adrenergic Receptor Autoantibodies (pages 248–262): Len C. Harrison, Judy Callaghan, J. Craig Venter, Claire M. Fraser and Michael L Kaliner
Chapter 15 Prolactin and progress Hormone Receptors (pages 263–278): H. G. Friesen, R. P. C. Shiu, H. Elsholtz, S. Simpson and J. Hughes
Chapter sixteen Speculations on capability Anti?Receptor Autoimmune illnesses (pages 279–300): Melvin Blecher

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Extra resources for Ciba Foundation Symposium 90 - Receptors, Antibodies and Disease

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It is worth drawing attention to a distinctive feature of organ-specific autoimmune diseases, namely their tendency to be associated in individual patients. Thus patients with thyrotoxicosis have a far greater chance of developing pernicious anaemia than do subjects without thyroid autoimmunity, while thyroid autoantibodies and disease are found with an uncommonly high frequency in patients with pernicious anaemia. Likewise, the first-degree relatives of these latter patients reveal a striking incidence of autoantibodies directed to both stomach and thyroid.

Harrison: I am interested in the implications of your comments in relation to the ability to make autoantibodies. Do you think that the autoantibodies to thyroglobulin and DNA are just the tip of the iceberg and that we see them because of the high circulating concentration of autoantigens? In other words, getting back to the concept of forbidden clones, are there clonal deletions that we cannot ever compensate for in adult life? Are we able to make antibodies to the total repertoire of antigens that we are exposed to in, say, neonatal life?

A recent paper by Lane et a1 (1981) describes the response of lymphoid cells from human subjects sensitized to keyhole limpet haemocyanin. The levels of this antigen that are normally used to stimulate mitosis in lymphoid cells are orders of magnitude too high to stimulate antibody formation; so there are very critical dose ranges. Bottuzzo: I would like to stress the point that circulating autoantibodies do not necessarily imply progression to overt disease. There may be degrees of abnormality of the regulating T cell network.

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